Publications

Articles

  1. Yanagida K, Igarashi H, Yasuda D, Kobayashi D, Ohto-Nakanishi T, Akahoshi N, Sekiba A, Toyoda T, Ishijima T, Nakai Y, Shojima N, Kubota N, Abe K, Kadowaki T, Ishii S, Shimizu T. The Gα12/13-coupled receptor, LPA4 limits proper adipose tissue expansion and remodeling in diet-induced obesity. JCI Insight, in press (2018)
  2. Yoshida K, Kita Y, Tokuoka SM, Hamano F, Yamazaki M, Sakimura K, Kano M, Shimizu T. Monoacylglycerol lipase deficiency affects diet-induced obesity, fat absorption, and feeding behavior in CB1 cannabinoid receptor-deficient mice. FASEB J, in press (2018)
  3. Kita Y, Shiudou H, Shimizu T. Cytosolic phospholipase A2 and lysophospholipid acyltransferases. Biochim Biophys Acta, in press (2018)
  4. Hori T, Okuno T, Hirata K, Yamashita K, Kawano Y, Yamamoto M, Hato M, Nakamura M, Shimizu T, Yokomizo T, Miyano M, Yokoyama S. Na+-mimicking ligands stabilize the inactive state of leukotriene B4 receptor BLT1. Nat Chem Biol, 14, 262–269 (2018)
  5. Valentine WV, Tokuoka SM, Hishikawa D, Kita Y, Shindou H, Shimizu T. Lysophosphatidic acid acyltransferase 3 incorporates docosahexaeneoic acid into skeletal muscle cell membranes and is upregulated by PPARδ activation. J Lipid Res, 59, 184-194 (2018)
  6. Tabe S, Hikiji H, Ariyoshi W, Hashidate-Yoshida T, Shindou H, Shimizu T, Okinaga T, Seta Y, Tominaga K, Nishihara T. Lysophosphatidylcholine acyltransferase 4 is involved in chondrogenic differentiation of ATDC5 cells. Sci Rep, 7, 16701 (2017)
  7. Kimura H, Suzuki M, Konno S, Shindou H, Shimizu T, Nagase T, Miyazaki T, Nishimura M. Orchestrating role of apoptosis inhibitor of macrophage in the resolution of acute lung injury. J Immunol, 199, 3870-3882 (2017)
  8. Iizuka-Hishikawa Y, Hishikawa D, Sasaki J, Takubo K, Goto M, Nagata K, Nakanishi H, Shindou H, Okamura T, Ito C, Toshimori K, Sasaki T, Shimizu T. Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis. J Biol Chem, 292, 12065-12076 (2017)
  9. Shindou H, Koso H, Sasaki J, Nakanishi H, Sagara H, Nakagawa MK, Takahashi Y, Hishikawa D, Iizuka-Hishikawa Y, Tokumasu F, Noguchi H, Watanabe S, Sasaki T, Shimizu T. Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells. J Biol Chem, 292, 12054-12064 (2017)
  10. Takeda T, Komiya Y, Koga T, Ishida T, Ishii Y, Kikuta Y, Nakaya M, Kurose H, Yokomizo T, Shimizu T, Uchi H, Furue M, Yamada H. Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration. J Biol Chem, 292. 10586-10599 (2017)
  11. Shindou H, Shiraishi S, Tokuoka MS, Takahashi Y, Harayama T, Abe T, Bando K, Miyano K, Kita Y, Uezono Y, Shimizu T. Relief from neuropathic pain by blocking of platelet-activating factor-pain loop. FASEB J, 31, 2973-2980 (2017)
  12. Shimura M, Shindou H, Szyrwiel L, Tokuoka MS, Hamano F, Matsuyama S, Okamoto M, Matsunaga A, Kita Y, Ishizaka Y, Yamauchi K, Komura Y, Lobinski R, Shimizu I, Shimizu T Imaging of intracellular fatty acids by scanning X-ray fluorescence microscopy. FASEB J, 30, 4149-4158 (2016)
  13. Kojo K, Ito Y, Eshima K, Nishizawa N, Ohkubo H, Yokomizo T, Shimizu T, Watanabe M, Majima M. BLT1 signalling protects the liver against acetaminophen hepatotoxicity by preventing excessive accumulation of hepatic neutrophils. Sci Rep, 6, 29650 (2016)
  14. Tabe S, Hikiji H, Ariyoshi W, Hashidate-Yoshida T, Shindou H, Okinaga T, Shimizu T, Tominaga K, Nishihara T. Lysophosphatidylethanolamine acyltransferase 1/membrane bound O-acyltransferase 1 regulates morphology and function of P19C6 cell-derived neurons. FASEB J, 30, 2591-601 (2016)
  15. Akagi S, Kono N, Ariyama H, Shindou H, Shimizu T, Arai H. Lysophosphatidylcholine acyltransferase 1 protects against cytotoxicity induced by polyunsaturated fatty acids. FASEB J, 30, 2027-39 (2016)
  16. Hori T, Nakamura M, Yokomizo T, Shimizu T, Miyano M. The leukotriene B4 receptor BLT1 is stabilized by transmembrane helix capping mutations. Biochem Biophys Rep, 4, 243-249 (2015)
  17. Kita Y, Yoshida K, Tokuoka MS, Hamano F, Yamazaki M, Sakimura K, Kano M, Shimizu T. Fever is mediated by conversion of endocannabinoid 2-arachidonoylglycerol to prostaglandin E2. PLoS ONE, 10, e0133663 (2015)
  18. Harayama T, Shindou H, Kita Y, Otsubo E, Ikeda K, Chiba S, Weaver T, Shimizu T. Establishment of LC-MS method for the analysis of palmitoylated surfactant proteins. J. Lipid Res., 56, 1370-1379 (2015)
  19. Yamada M, Kita Y, Kohira T, Yoshida K, Hamano F, Tokuoka SM, Shimizu T. A comprehensive quantification method for eicosanoids and related compounds by using liquid chromatography/mass spectrometry with high speed continuous ionization polarity switching. J Chrom B, 995, 74-84 (2015)
  20. Hashidate-Yoshida T, Harayama T, Hishikawa D, Morimoto R, Hamano F, Tokuoka SM, Eto M, Tamura-Nakano M, Yanobu-Takanashi R, Mukumoto Y, Kiyonari H, Okamura T, Kita Y, Shindou H, Shimizu T. Fatty acyl-chain remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport. eLife, 4, e06328 (2015)
  21. Hayakawa EH, Tokumasu F, Usukura J, Matsuoka H, Tsuboi T, Wellems TE. Imaging of the subsurface structures of "unroofed" plasmodium falciparum-infected erythrocytes. Exp. Parasitol., 153, 174-179 (2015)
  22. Asahara M, Ito N, Yokomizo T, Nakamura M, Shimizu T, Yamada Y. The absence of the leukotriene B4 receptor BLT1 attenuates peripheral inflammation and spinal nociceptive processing following intraplantar formalin injury. Molecular Pain, 11.11 (2015)
  23. Yasuda D, Imura Y, Ishii S, Shimizu T, Nakamura M. The atypical N-glycosylation motif, Asn-Cys-Cys, in human GPR109A is required for normal cell surface expression and intracellular signaling. FASEB J., 29, 2412-2422 (2015)
  24. Koeberle A, Pergola C, Shindou H, Koeberle SC, Shimizu T, Laufer SA, Werz O. Role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with ER homeostasis. FASEB J., 29, 2439-2449 (2015)
  25. Chagas AC, McPhie P, San H, Narum D, Reiter K, Tokumasu F, Brayner FA, Alves LC, Ribeiro JM, Calvo E. Simplagrin, a platelet aggregation inhibitor from Simulium nigrimanum salivary glands specifically binds to the Von Willebrand factor receptor in collagen and inhibits carotid thrombus formation in vivo. PLoS Negl Trop Dis, 8, e2947 (2014)
  26. Tokumasu F, Crivat G, Ackerman H, Hwang J, Wellems TE. Inward cholesterol gradient of the membrane system in P. falciparum-infected erythrocytes involves a dilution effect from parasite-produced lipids. Biol Open, 3, 529-541 (2014)
  27. Yoshioka W, Kawaguchi T, Fujisawa N, Aida-Yasuoka K, Shimizu T, Matsumura F, Tohyama C. Predominant role of cytosolic phospholipase A2α in dioxin-induced neonatal hydronephrosis in mice. Sci Rep, 4, 4042 (2014)
  28. Tarui M, Shindou H, Kumagai K, Morimoto R, Harayama T, Hashidate T, Kojima H, Okabe T, Nagano T, Nagase T, Shimizu T. Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2. J Lipid Res, 55, 1386-1396 (2014)
  29. Harayama T, Eto M, Shindou H, Kita Y, Otsubo E, Hishikawa D, Ishii S, Sakimura K, Mishina M, Shimizu T. Lysophospholipid acyltransferases mediate phosphatidylcholine diversification to achieve the physical properties required in vivo. Cell Metab., 20, 295-305 (2014)
  30. Morimoto R, Shindou H, Tarui M, Shimizu T. Rapid production of platelet-activating factor is induced by protein kinase Cα-mediated phosphorylation of lysophosphatidylcholine acyltransferase 2 protein. J Biol Chem, 289, 15566-15576 (2014)
  31. Liu M, Saeki K, Matsunobu T, Okuno T, Koga T, Sugimoto Y, Yokoyama C, Nakamizo S, Kabashima K, Narumiya S, Shimizu T, Yokomizo T. 12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via BLT2 receptor. J Exp Med, 211, 1063-1078 (2014)
  32. Sumida H, Yanagida K, Kita Y, Abe J, Matsushima K, Nakamura M, Ishii S, Sato S, Shimizu T. Interplay between CXCR2 and BLT1 facilitates neutrophil infiltration and resultant keratinocyte activation in a murine model of imiquimod-induced psoriasis. J Immunol 192, 4361-4369 (2014)
  33. Eto M, Shindou H, Shimizu T. A novel lysophosphatidic acid acyltransferase enzyme (LPAAT4) with a possible role for incorporating docosahexaenoic acid into brain glycerophospholipids. Biochem Biophys Res Commun, 443, 718-724 (2014)
  34. Sugatani J, Sadamitsu S, Yamaguchi M, Yamazaki Y, Higa R, Hattori Y, Uchida T, Ikari A, Sugiyama W, Watanabe T, Ishii S, Miwa M, Shimizu T. Antiobese function of platelet-activating factor: increased adiposity in platelet-activating factor receptor-deficient mice with age. FASEB J, 28, 440-452 (2014)
  35. Hikiji H, Endo D, Horie K, Harayama T, Akahoshi N, Igarashi H, Kihara Y, Yanagida K, Takeda J, Koji T, Shimizu T, Ishii S. TDAG8 activation inhibits osteoclastic bone resorption. FASEB J, 28, 871-879 (2014)
  36. Tokuoka SM, Kita Y, Shindou H, Shimizu T. Alkylglycerol monooxygenase as a potential modulator for PAF synthesis in macrophages. Biochem Biophys Res Commun, 436, 306-312 (2013)
  37. Yoshikawa K, Kita Y, Furukawa A, Kawamura N, Hasegawa-Ishii S, Chiba Y, Takei S, Maruyama K, Shimizu T, Shimada A. Excitotoxicity-induced immediate surge in hippocampal prostanoid production has latent effects that promote chronic progressive neuronal death. Prostaglandins Leukot Essent Fatty Acids, 88, 373-381 (2013)
  38. Echigo R, Shimohata N, Karatsu K, Yano F, Kayasuga-Kariya Y, Fujisawa A, Ohto T, Kita Y, Nakamura M, Suzuki S, Mochizuki M, Shimizu T, Chung U, Sasaki N. Trehalose treatment suppresses inflammation, oxidative stress, and vasospasm induced by experimental subarachnoid hemorrhage. J Transl Med, 10, 80 (2012)
  39. Saito Y, Watanabe K, Fujioka D, Nakamura T, Obata J, Kawabata K, Watanabe Y, Mishina H, Tamaru S, Kita Y, Shimizu T, Kugiyama K. Disruption of group IVA cytosolic phospholipase A2 attenuates myocardial ischemia-reperfusion injury partly through inhibition of TNFα-mediated pathway. Am J Physiol Heart Circ Physiol, 302, H2018-H2030 (2012)
  40. Jönsson F, Mancardi DA, Zhao W, Kita Y, Iannascoli B, Khun H, van Rooijen N, Shimizu T, Schwartz LB, Daëron M, Bruhns P. Human FcγRIIA induces anaphylactic and allergic reactions. Blood, 119, 2533-2544 (2012)
  41. Ueno N, Taketomi Y, Yamamoto K, Hirabayashi T, Kamei D, Kita Y, Shimizu T, Shinzawa K, Tsujimoto Y, Ikeda K, Taguchi R, Murakami M. Analysis of two major intracellular phospholipase A2s in mast cells reveals crucial contribution of cPLA2α, not iPLA2β, to lipid mobilization in proximal mast cells and distal fibroblasts. J Biol Chem, 286, 37249-37263 (2011)

International conferences and meetings