研究業績

論文

  1. Kita Y, Tokuoka SM, Oda Y, Shimizu T. TRACES: A lightweight browser for liquid chromatography–multiple reaction monitoring–mass spectrometry chromatograms. Metabolites, 12, 354 (2022) (Published: 15 April 2022)
  2. Tokuoka SM, Kita Y, Sato M, Shimizu T, Yatomi Y, Oda Y. Lipid profiles of human serum fractions enhanced with CD9 antibody-immobilized magnetic beads. Metabolites, 12, 230 (2022) (Published: 5 March 2022)
  3. Hamano F, Tokuoka SM, Ishibashi M, Yokoi Y, Tourlousse DM, Kita Y, Sekiguchi Y, Yasui H, Shimizu T, Oda Y. Multi-omics analysis to generate hypotheses for mild health problems in monkeys. Metabolites, 11, 701 (2021) (Published: 13 October 2021)
  4. Tokuoka SM, Kita Y, Sato M, Shimizu T, Yatomi Y, Oda Y. Development of tandem mass tag labeling method for lipid molecules containing carboxy and phosphate groups, and their stability in human serum. Metabolites, 11, 19 (2021) (Published: 30 December 2020)
  5. Serhan CN, Gupta SK, Perretti M, Godson C, Brennan E, Li Y, Soehnlein O, Shimizu T, Werz O, Chiurchiù V, Azzi A, Dubourdeau M, Gupta SS, Schopohl P, Hoch M, Gjorgevikj D, Khan FM, Brauer D, Tripathi A, Cesnulevicius K, Lescheid D, Schultz M, Särndahl E, Repsilber D, Kruse R, Sala A, Haeggström JZ, Levy BD, Filep JG, Wolkenhauer O. The Atlas of Inflammation Resolution (AIR) Mol. Asp. Med., 74, 100894 (2020) (Available online 3 September 2020)
  6. Hishikawa D, Yanagida K, Nagata K, Kanatani A, Iizuka Y, Hamano F, Yasuda M, Okamura T, Shindou H, Shimizu T. Hepatic levels of DHA-containing phospholipids instruct SREBP1-mediated synthesis and systemic delivery of polyunsaturated fatty acids. iScience, 23, 101495 (2020) (First published:22 August 2020)
  7. Harayama T, Shimizu T. Roles of polyunsaturated fatty acids, from mediators to membrane. J Lipid Res, 61, 1150-1160 (2020) (First published:2 June 2020)
  8. Tokuoka SM, Yasumoto A, Kita Y, Shimizu T, Yatomi Y, Oda Y. Limitations of deuterium-labeled internal standards for quantitative electrospray ionization mass spectrometry analysis of fatty acid metabolites. Rapid Commun Mass Sp, 34, e8814 (2020) (First published:19 April 2020, Available Online:25 May 2020)
  9. Hamano F, Tokuoka SM, Hashidate-Yoshida T, Shindou H, Shimizu T, Kita Y. Quantification of Fatty Acids in Mammalian Tissues by Gas Chromatography–Hydrogen Flame Ionization Detection. Bio Protoc, 10, e2734 (2020) (Published:5 May 2020)
  10. Tokuoka SM, Kita Y, Shimizu T, Oda Y. Isobaric mass tagging and triple quadrupole mass spectrometry to determine lipid biomarker candidates for Alzheimer's disease. PLoS ONE, 14, e0226073 (2019) (Published:10 December 2019)
  11. Izumi Y, Matsuda F, Hirayama A, Ikeda K, Kita Y, Horie K, Saigusa D, Saito K, Sawada Y, Nakanishi H, Okahashi N, Takahashi M, Nakao M, Hata K, Hoshi Y, Morihara M, Tanabe K, Bamba T, Oda Y. Inter-Laboratory Comparison of Metabolite Measurements for Metabolomics Data Integration. Metabolites, 9, 257 (2019) (Published Online:31 October 2019)
  12. Tanaka TQ, Tokuoka SM, Nakatani D, Hamano F, Kawazu S, Wellems TE, Kita K, Shimizu T, Tokumasu F. Polyunsaturated fatty acids promote Plasmodium falciparum gametocytogenesis. Biol. Open, 8, bio042259 (2019) (Published Online:20 June 2019)
  13. Kohira T, Kita Y, Tokuoka SM, Shiba M, Satake M, Shimizu T. Characterization of supported liquid extraction as a sample pretreatment method for eicosanoids and related metabolites in biological fluids. J Chrom B, 1124, 298-307 (2019) (Published Online:12 Jun 2019)
  14. Yoshida K, Kita Y, Tokuoka SM, Hamano F, Yamazaki M, Sakimura K, Kano M, Shimizu T. Monoacylglycerol lipase deficiency affects diet-induced obesity, fat absorption, and feeding behavior in CB1 cannabinoid receptor-deficient mice. FASEB J, 33, 2484-2497 (2019) (Published Online:30 Jan 2019)
  15. Yanagida K, Igarashi H, Yasuda D, Kobayashi D, Ohto-Nakanishi T, Akahoshi N, Sekiba A, Toyoda T, Ishijima T, Nakai Y, Shojima N, Kubota N, Abe K, Kadowaki T, Ishii S, Shimizu T. The Gα12/13-coupled receptor, LPA4 limits proper adipose tissue expansion and remodeling in diet-induced obesity. JCI Insight, 3, e97293 (2018) (First published December 20, 2018)
  16. Kita Y, Shiudou H, Shimizu T. Cytosolic phospholipase A2 and lysophospholipid acyltransferases. Biochim Biophys Acta, 1864, 838-845 (2019) (Available online 9 August 2018)
  17. Hori T, Okuno T, Hirata K, Yamashita K, Kawano Y, Yamamoto M, Hato M, Nakamura M, Shimizu T, Yokomizo T, Miyano M, Yokoyama S. Na+-mimicking ligands stabilize the inactive state of leukotriene B4 receptor BLT1. Nat Chem Biol, 14, 262–269 (2018)
  18. Valentine WV, Tokuoka SM, Hishikawa D, Kita Y, Shindou H, Shimizu T. Lysophosphatidic acid acyltransferase 3 incorporates docosahexaeneoic acid into skeletal muscle cell membranes and is upregulated by PPARδ activation. J Lipid Res, 59, 184-194 (2018)
  19. Tabe S, Hikiji H, Ariyoshi W, Hashidate-Yoshida T, Shindou H, Shimizu T, Okinaga T, Seta Y, Tominaga K, Nishihara T. Lysophosphatidylcholine acyltransferase 4 is involved in chondrogenic differentiation of ATDC5 cells. Sci Rep, 7, 16701 (2017)
  20. Kimura H, Suzuki M, Konno S, Shindou H, Shimizu T, Nagase T, Miyazaki T, Nishimura M. Orchestrating role of apoptosis inhibitor of macrophage in the resolution of acute lung injury. J Immunol, 199, 3870-3882 (2017)
  21. Iizuka-Hishikawa Y, Hishikawa D, Sasaki J, Takubo K, Goto M, Nagata K, Nakanishi H, Shindou H, Okamura T, Ito C, Toshimori K, Sasaki T, Shimizu T. Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis. J Biol Chem, 292, 12065-12076 (2017)
  22. Shindou H, Koso H, Sasaki J, Nakanishi H, Sagara H, Nakagawa MK, Takahashi Y, Hishikawa D, Iizuka-Hishikawa Y, Tokumasu F, Noguchi H, Watanabe S, Sasaki T, Shimizu T. Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells. J Biol Chem, 292, 12054-12064 (2017)
  23. Takeda T, Komiya Y, Koga T, Ishida T, Ishii Y, Kikuta Y, Nakaya M, Kurose H, Yokomizo T, Shimizu T, Uchi H, Furue M, Yamada H. Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration. J Biol Chem, 292. 10586-10599 (2017)
  24. Shindou H, Shiraishi S, Tokuoka MS, Takahashi Y, Harayama T, Abe T, Bando K, Miyano K, Kita Y, Uezono Y, Shimizu T. Relief from neuropathic pain by blocking of platelet-activating factor-pain loop. FASEB J, 31, 2973-2980 (2017)
  25. Shimura M, Shindou H, Szyrwiel L, Tokuoka MS, Hamano F, Matsuyama S, Okamoto M, Matsunaga A, Kita Y, Ishizaka Y, Yamauchi K, Komura Y, Lobinski R, Shimizu I, Shimizu T Imaging of intracellular fatty acids by scanning X-ray fluorescence microscopy. FASEB J, 30, 4149-4158 (2016)
  26. Kojo K, Ito Y, Eshima K, Nishizawa N, Ohkubo H, Yokomizo T, Shimizu T, Watanabe M, Majima M. BLT1 signalling protects the liver against acetaminophen hepatotoxicity by preventing excessive accumulation of hepatic neutrophils. Sci Rep, 6, 29650 (2016)
  27. Tabe S, Hikiji H, Ariyoshi W, Hashidate-Yoshida T, Shindou H, Okinaga T, Shimizu T, Tominaga K, Nishihara T. Lysophosphatidylethanolamine acyltransferase 1/membrane bound O-acyltransferase 1 regulates morphology and function of P19C6 cell-derived neurons. FASEB J, 30, 2591-601 (2016)
  28. Akagi S, Kono N, Ariyama H, Shindou H, Shimizu T, Arai H. Lysophosphatidylcholine acyltransferase 1 protects against cytotoxicity induced by polyunsaturated fatty acids. FASEB J, 30, 2027-39 (2016)
  29. Hori T, Nakamura M, Yokomizo T, Shimizu T, Miyano M. The leukotriene B4 receptor BLT1 is stabilized by transmembrane helix capping mutations. Biochem Biophys Rep, 4, 243-249 (2015)
  30. Kita Y, Yoshida K, Tokuoka MS, Hamano F, Yamazaki M, Sakimura K, Kano M, Shimizu T. Fever is mediated by conversion of endocannabinoid 2-arachidonoylglycerol to prostaglandin E2. PLoS ONE, 10, e0133663 (2015)
  31. Harayama T, Shindou H, Kita Y, Otsubo E, Ikeda K, Chiba S, Weaver T, Shimizu T. Establishment of LC-MS method for the analysis of palmitoylated surfactant proteins. J. Lipid Res., 56, 1370-1379 (2015)
  32. Yamada M, Kita Y, Kohira T, Yoshida K, Hamano F, Tokuoka SM, Shimizu T. A comprehensive quantification method for eicosanoids and related compounds by using liquid chromatography/mass spectrometry with high speed continuous ionization polarity switching. J Chrom B, 995, 74-84 (2015)
  33. Hashidate-Yoshida T, Harayama T, Hishikawa D, Morimoto R, Hamano F, Tokuoka SM, Eto M, Tamura-Nakano M, Yanobu-Takanashi R, Mukumoto Y, Kiyonari H, Okamura T, Kita Y, Shindou H, Shimizu T. Fatty acyl-chain remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport. eLife, 4, e06328 (2015)
  34. Hayakawa EH, Tokumasu F, Usukura J, Matsuoka H, Tsuboi T, Wellems TE. Imaging of the subsurface structures of "unroofed" plasmodium falciparum-infected erythrocytes. Exp. Parasitol., 153, 174-179 (2015)
  35. Asahara M, Ito N, Yokomizo T, Nakamura M, Shimizu T, Yamada Y. The absence of the leukotriene B4 receptor BLT1 attenuates peripheral inflammation and spinal nociceptive processing following intraplantar formalin injury. Molecular Pain, 11.11 (2015)
  36. Yasuda D, Imura Y, Ishii S, Shimizu T, Nakamura M. The atypical N-glycosylation motif, Asn-Cys-Cys, in human GPR109A is required for normal cell surface expression and intracellular signaling. FASEB J., 29, 2412-2422 (2015)
  37. Koeberle A, Pergola C, Shindou H, Koeberle SC, Shimizu T, Laufer SA, Werz O. Role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with ER homeostasis. FASEB J., 29, 2439-2449 (2015)
  38. Chagas AC, McPhie P, San H, Narum D, Reiter K, Tokumasu F, Brayner FA, Alves LC, Ribeiro JM, Calvo E. Simplagrin, a platelet aggregation inhibitor from Simulium nigrimanum salivary glands specifically binds to the Von Willebrand factor receptor in collagen and inhibits carotid thrombus formation in vivo. PLoS Negl Trop Dis, 8, e2947 (2014)
  39. Tokumasu F, Crivat G, Ackerman H, Hwang J, Wellems TE. Inward cholesterol gradient of the membrane system in P. falciparum-infected erythrocytes involves a dilution effect from parasite-produced lipids. Biol Open, 3, 529-541 (2014)
  40. Yoshioka W, Kawaguchi T, Fujisawa N, Aida-Yasuoka K, Shimizu T, Matsumura F, Tohyama C. Predominant role of cytosolic phospholipase A2α in dioxin-induced neonatal hydronephrosis in mice. Sci Rep, 4, 4042 (2014)
  41. Tarui M, Shindou H, Kumagai K, Morimoto R, Harayama T, Hashidate T, Kojima H, Okabe T, Nagano T, Nagase T, Shimizu T. Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2. J Lipid Res, 55, 1386-1396 (2014)
  42. Harayama T, Eto M, Shindou H, Kita Y, Otsubo E, Hishikawa D, Ishii S, Sakimura K, Mishina M, Shimizu T. Lysophospholipid acyltransferases mediate phosphatidylcholine diversification to achieve the physical properties required in vivo. Cell Metab., 20, 295-305 (2014)
  43. Morimoto R, Shindou H, Tarui M, Shimizu T. Rapid production of platelet-activating factor is induced by protein kinase Cα-mediated phosphorylation of lysophosphatidylcholine acyltransferase 2 protein. J Biol Chem, 289, 15566-15576 (2014)
  44. Liu M, Saeki K, Matsunobu T, Okuno T, Koga T, Sugimoto Y, Yokoyama C, Nakamizo S, Kabashima K, Narumiya S, Shimizu T, Yokomizo T. 12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via BLT2 receptor. J Exp Med, 211, 1063-1078 (2014)
  45. Sumida H, Yanagida K, Kita Y, Abe J, Matsushima K, Nakamura M, Ishii S, Sato S, Shimizu T. Interplay between CXCR2 and BLT1 facilitates neutrophil infiltration and resultant keratinocyte activation in a murine model of imiquimod-induced psoriasis. J Immunol 192, 4361-4369 (2014)
  46. Eto M, Shindou H, Shimizu T. A novel lysophosphatidic acid acyltransferase enzyme (LPAAT4) with a possible role for incorporating docosahexaenoic acid into brain glycerophospholipids. Biochem Biophys Res Commun, 443, 718-724 (2014)
  47. Sugatani J, Sadamitsu S, Yamaguchi M, Yamazaki Y, Higa R, Hattori Y, Uchida T, Ikari A, Sugiyama W, Watanabe T, Ishii S, Miwa M, Shimizu T. Antiobese function of platelet-activating factor: increased adiposity in platelet-activating factor receptor-deficient mice with age. FASEB J, 28, 440-452 (2014)
  48. Hikiji H, Endo D, Horie K, Harayama T, Akahoshi N, Igarashi H, Kihara Y, Yanagida K, Takeda J, Koji T, Shimizu T, Ishii S. TDAG8 activation inhibits osteoclastic bone resorption. FASEB J, 28, 871-879 (2014)
  49. Tokuoka SM, Kita Y, Shindou H, Shimizu T. Alkylglycerol monooxygenase as a potential modulator for PAF synthesis in macrophages. Biochem Biophys Res Commun, 436, 306-312 (2013)
  50. Yoshikawa K, Kita Y, Furukawa A, Kawamura N, Hasegawa-Ishii S, Chiba Y, Takei S, Maruyama K, Shimizu T, Shimada A. Excitotoxicity-induced immediate surge in hippocampal prostanoid production has latent effects that promote chronic progressive neuronal death. Prostaglandins Leukot Essent Fatty Acids, 88, 373-381 (2013)
  51. Echigo R, Shimohata N, Karatsu K, Yano F, Kayasuga-Kariya Y, Fujisawa A, Ohto T, Kita Y, Nakamura M, Suzuki S, Mochizuki M, Shimizu T, Chung U, Sasaki N. Trehalose treatment suppresses inflammation, oxidative stress, and vasospasm induced by experimental subarachnoid hemorrhage. J Transl Med, 10, 80 (2012)
  52. Saito Y, Watanabe K, Fujioka D, Nakamura T, Obata J, Kawabata K, Watanabe Y, Mishina H, Tamaru S, Kita Y, Shimizu T, Kugiyama K. Disruption of group IVA cytosolic phospholipase A2 attenuates myocardial ischemia-reperfusion injury partly through inhibition of TNFα-mediated pathway. Am J Physiol Heart Circ Physiol, 302, H2018-H2030 (2012)
  53. Jönsson F, Mancardi DA, Zhao W, Kita Y, Iannascoli B, Khun H, van Rooijen N, Shimizu T, Schwartz LB, Daëron M, Bruhns P. Human FcγRIIA induces anaphylactic and allergic reactions. Blood, 119, 2533-2544 (2012)
  54. Ueno N, Taketomi Y, Yamamoto K, Hirabayashi T, Kamei D, Kita Y, Shimizu T, Shinzawa K, Tsujimoto Y, Ikeda K, Taguchi R, Murakami M. Analysis of two major intracellular phospholipase A2s in mast cells reveals crucial contribution of cPLA2α, not iPLA2β, to lipid mobilization in proximal mast cells and distal fibroblasts. J Biol Chem, 286, 37249-37263 (2011)

学会発表

　　　（準備中）

日本語総説・等

  1. 古市真木雄、和賀巌、小田吉哉　アプタマー技術による大規模疾患プロテオミクス　日本プロテオーム学会誌 5(2), 55-63 (2020)
  2. 徳岡涼美、小田吉哉　最先端の研究テクノロジー紹介⑨—疾患メタボロミクス　LiSA 27(7), 759-771 (2020)
  3. 小田吉哉　Precision Medicineにおけるバイオマーカー　ファルマシア 55, 1139-1144 (2019)
  4. 北芳博、清水孝雄　エイコサノイドの高感度一斉定量法　臨床検査 56, 177-187 (2012)